Results 1 - 10 for Mevalonic acid

Allogeneic Bone Marrow Transplantation in Mevalonic Aciduria
In addition, mevalonic acid is excreted in the urine only during febrile attacks, and mevalonate kinase activity is less severely impaired in HIDS than in mevalonic aciduria ...
http://content.nejm.org/cgi/reprint/356/26/2700.pdf
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John Warcup Cornforth - Nobel Lecture
Later, and especially when mevalonic acid emerged as the parent substance of steroids and terpenoids, we were able to plan experiments of greater subtlety, using mevalonic acid ...
http://nobelprize.org/nobel_prizes/chemistry/laureates/1975/cornforth-lecture.pdf
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New Target for Anti-Cholesterol Drugs, Antibiotics
mevalonic acid metabolic pathway—the chemical factory that churns out isoprenoids—is the strategy behind the powerful effects of some top selling cholesterol-lowering drugs.
http://www.hhmi.org/news/pdf/noel20060717.pdf
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Group IVC cytosolic phospholipase A
Inhibition of [3 H]mevalonic acid labeling of cPLA 2 * with the protein farnesyltransferase inhibitor BMS-214662. IMLF */* were infected with Ad-cPLA 2 * and incubated with or without 1 *M ...
http://faculty.washington.edu/gelb/2005/tucker-JLR_2005.pdf
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MERCK MANUALS
... Mevalonic aciduria (251170, 260920) Mevalonate kinase MVK (12q24) * Biochemical profile: Elevated creatine kinase, transaminase, leukotriene, and urinary mevalonic acid; decreased ...
http://www.merck.com/media/mmpe/pdf/Table_296-1w.pdf
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A Biographical Memoir by
This group discovered, isolated, and synthesized mevalonic acid as an acetate-replacing factor for growth of certain Lactobacilli. The relationship of this factor to the ...
http://www.nap.edu/html/biomems/kfolkers.pdf
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DRAFT SUMMARY OF REPRO-TOX ST+,,
The higher maternal or fetal inhibition of mevalonic acid (effect of HMG-CoA inhibition) also had nothing to do with maternal or fetal toxicity, because mevalonic acid inhibition was ...
http://www.fda.gov/ohrms/dockets/ac/00/backgrd/3622b1b_summary.pdf
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Lipoprotein cholesteryl ester production, transfer, and output in vivo ...
Specific activity time courses after administration of isotopic free cholesterol and mevalonic acid The time courses for free cholesterol specific activity in *- and *-lipoprotein ...
http://www.jlr.org/cgi/reprint/45/9/1594.pdf
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Homocysteine-Lowering Vitamins:
It impedes the formation of mevalonic acid, which is the rate-limiting step in the biosynthesis of cholesterol. The reduction in intracellular cholesterol increases the number of low ...
http://www.centaurpharma.com/pdf/ENDOCHEK%20-%20prescribing%20info.pdf
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Evidence fora phenotypic continuum
Analysis of mevalonate kinase gene mutations, enzyme activity, and urinary mevalonic acid. Genomic DNA was extracted from whole blood or Epstein-Barr-immortalized lymphoblasts from the ...
http://hids.net/publications/Neurology%202004.pdf
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